There is no place in the match-day squad for inside centre Cam Redpath and No 8 Magnus Bradbury has to be content with a place on the bench as the Scotland head coach sticks with Sam Johnson and Matt Fagerson, respectively.
Loosehead prop Rory Sutherland returns to the side for the Guinness Six Nations opener after missing the autumn Tests with an oblique muscle injury.
Jonny Gray is also back in the starting line up, for the first time since March 2021, and there is a potential debutant, with the uncapped London Irish scrum-half Ben White named among the replacements.
There is a 5:3 forwards/backs split on the bench, with Sione Tuipulotu and Blair Kinghorn joining White as backline cover.
13. Chris Harris
Bulwark in the backline, Harris has been one of Scotland’s most consistent performers in recent years. Photo: Craig Williamson - SNS Group / SRU
14. Darcy Graham
Livewire winger has scored ten tries in 22 Tests, including a double against England at Twickenham in the 2019 draw. Photo: Craig Williamson - SNS Group / SRU
15. Stuart Hogg
Captain and Scotland’s all-time leading try scorer after grabbing his 25th in the November win over Japan. Photo: Craig Williamson - SNS Group / SRU
16. The replacements
16.Stuart McInally, 17. Pierre Schoeman, 18. WP Nel, 19. Sam Skinner, 20. Magnus Bradbury, 21. Ben White, 22 Blair Kinghorn (pictured), 23 Sione Tuipulotu. Photo: Craig Williamson - SNS Group / SRU