Double try scorer Duhan van der Merwe plundered his decisive second score in the 74th minute as Scotland came from behind to take the spoils. The marauding Lions wing had already brought Twickenham to its feet with a stunning first-half score that began in his own half and saw five would-be tacklers beaten by his speed, strength and footwork.
Huw Jones and Ben White also got themselves on the scoresheet, while Finn Russell landed nine points with the boot as Scotland defeated the Auld Enemy for the third year in a row.
We give each player involved in this famous victory a mark out of ten for their performance at Twickenham.
13. Huw Jones
Loves a try against England. This was his fifth in five games, justifying his selection ahead of Chris Harris - 7. Photo: Julian Finney
14. Kyle Steyn
Had a tough task to take over from the injured Darcy Graham but responded impressively and was a regular threat - 7. Photo: Julian Finney
15. Stuart Hogg
Was frustrated to be taken off early but played his part in a historic win. One excellent break in second half should have yielded a try but his pass to Steyn went awry - 7. Photo: Glyn Kirk
16. The replacements
All played a key role in wresting back control from England who led with five minutes to go. Jack Dempsey and the new front row were particularly influential but Blair Kinghorn, pictured above, also stood up well. Photo: Adam Davy