The Rangers boss has made three changes to the side which defeated St Johnstone 1-0 during the week, courtesy of goal form Ianis Hagi.
There are starts for Bongani Zungu and Cedric Itten, while Glen Kamara is restored to the starting XI after being named amongst the subs in midweek.
Out go Ryan Jack, Steven Davis and Kemar Roofe, who all start on the bench alongside new signings Scott Wright and Jack Simpson.
The league leaders can extend their lead over rivals Celtic back to 23 points following Saturday’s 2-1 win over Motherwell for Neil lennon’s men.
The match in Hamilton gets underway at 12pm on Sky Sports,
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9. Ianis Hagi
Is influence increases with each passing game. Netted the winner against St Johnstone during the week. Photo: Alan Harvey - SNS Group
10. Ryan Kent
Joint fourth in the Premiership with team-mate Kemar Roofe for goals and assists (12). Photo: Rob Casey - SNS Group
11. Cedric Itten
The Swiss ace averages 0.64 goals per 90 minutes, which is in the top ten of players in the Premiership. Photo: Craig Foy - SNS Group