New arrival Joe Hart has been handed a debut in goals while Kyogo Furuhashi has also been given his first start after making his debut off the bench in the weekend defeat to Hearts.
Another big call from the Greek-Australian coach sees Odsonne Edouard dropped to the bench with Furuhashi set to lead the attack.
Here is the Celtic starting XI for the big match against the Czech side:
5. DC - Nir Bitton
The Israel international was preferred to Stephen Welsh at Tynecastle and gets the nod again due to his experience in European competition Photo: Ross Parker - SNS Group
6. MC - Callum McGregor
The club captain scored a cracker in Denmark last week but it wasn't enough to spare Celtic from a Champions League exit. Photo: Claus Fisker - SNS Group
7. MC - Ismaila Soro
The Ivorian will look to dictate the game from the middle of the park Photo: Craig Williamson - SNS Group
8. AML - James Forrest
The wide man has scored some key European goals for Celtic over the years Photo: Ross MacDonald - SNS Group