The blaze broke out around 3.30pm in the former Camelon St John’s Church in Glasgow Road.
Police have closed off a stretch of the road in both directions from the Main Street at the Stirling Road roundabout to Hamilton Street to both traffic and pedestrians.
Part of nearby Brown Street is also closed.
Traffic is being diverted but police have urged people to stay away from the area.
At the height of the blaze four appliances from the Scottish Fire and Rescue Service were at the scene, along with the aerial platform.
Firefighters are still using the high rise platform to dampen down the building.
The roof appears to be totally destroyed with only the walls still standing.
A spokesperson for Police Scotland said: “Main Street, Camelon is closed following a fire, reported at around 3.30pm on Saturday, February 14.
“Diversions are in place along Hamilton Street.
“Please avoid the area.”
St John’s was last used by the Church of Scotland congregation in 2005 but closed after it merged with the Irving Church in Dorrator Road to form the united Camelon Parish Church.
The building was built in 1840 to accommodate 600 worshipers. It was designed by Scottish architect David Rhind and cost £1100.
It’s future has remained in doubt in recent years.
The Buildings at Risk Register for Scotland show that in 2011 the C-listed building was boarded up with many broken windows.
By 2013 there were plans lodged with Falkirk Council to retain the front of the building and demolish the rest of the existing structure with new build to create a worship centre, church, hall and community facilities.
Planning permission and listed building consent were conditionally granted by the council in March 2022 for alterations and extension the former church for use as community hub incorporating multi-purpose hall, meeting rooms and bar/cafe and erection of bin closure.
But it was understood to also be marketed for sale through the Church of Scotland for offers over £19,995.
By January 2023 the building was no longer listed for sale.
1. Camelon fire
Emergency services at the scene of the fire in Camelon. Photo: Michael Gillen
4. Camelon fire
Firefighters in the graveyard surrounding Camelon St John's Church. Photo: Michael Gillen