The building was found “well alight” and a total of 10 fire appliances have been sent to the scene on Rose Street in the city centre.
No casualties have been reported and some streets in the area have been closed.
We take a look inside the grand old building that has sat proudly on Princes Street.
9. 150th anniversary celebrations
Jenners staff can be seen here as they gather around a cake to celebrate the 150th anniversary of the store trading. Year: 1988 Photo: Bill Stout
10. The Queen visits the store
Queen Elizabeth II can be seen here chatting with Fred Lonie at the Edinburgh crystal department of Jenners as she visits the 150th anniversary exhibition. Year: 1988 Photo: Albert Jordan
11. Boxing day sales
Shoppers can be seen here fighting to find the best deals at the Boxing Day Sales in the store. Year: 1992 Photo: Graeme Hunter
12. Flags at half mast
The flags on the department store were lowered to half mast in order to honour the death of Princess Diana. Year: 1997 Photo: Tina Norris